Journal
HORMONE RESEARCH
Volume 54, Issue 5-6, Pages 263-268Publisher
KARGER
DOI: 10.1159/000053269
Keywords
PPAR gene expression; mouse epidermis; keratinocyte proliferation; skin wound healing
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PPAR beta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPAR beta heterozygous mice reveal that PPAR beta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound. Copyright (C) 2001 S. Karger AG, Basel.
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