Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 44, Issue 11, Pages 945-947Publisher
CENTER ACADEMIC PUBL JAPAN
DOI: 10.1111/j.1348-0421.2000.tb02587.x
Keywords
Staphylococcus aureus; atopic dermatitis; superantigen
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The skin of patients with atopic dermatitis (AD) is often colonized by Staphylococcus aureus, and superantigenic exotoxins produced by the organism are thought to be an important precipitating factor of AD. However, there are few reports comparing the characteristics of S, arrreus isolated from the lesional and non-lesional skin of identical AD patients. Tn this study, therefore, we examined whether the presence of superantigen-producing S, arrreus correlates with the formation of eczematous lesion of AD patients. The detection rate of S, aureus on the lesional skin of AD patients was higher than on the non-lesional skin of AD patients. Furthermore, the bacterial cell count of S, aureus on the lesional skin of AD patients was also significantly higher than that of the non-lesional skin of AD patients. However, there was no significant difference between the detection rate of superantigenic exotoxin-producing S, aureus on the lesional and nonlesional skin of AD patients. These results suggest that the number of S, aureus present is more important in the formation of eczematous lesion of AD patients than the presence of superantigenic exotoxin-producing S, aureus strains per se.
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