Journal
FREE RADICAL RESEARCH
Volume 33, Issue 5, Pages 661-665Publisher
HARWOOD ACAD PUBL GMBH
DOI: 10.1080/10715760000301171
Keywords
neutrophils; flow cytometry; reactive oxygen species; artichoke; Cynara scolymus; active constituents
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Artichoke leaf extract was studied in human leukocytes for activity against oxidative stress using flow cytometry and dichlorofluorescin diacetate as a fluorescence probe. It produces a concentration-dependent inhibition of oxidative stress when cells are stimulated with agents that generate reactive oxygen species (ROS): hydrogen peroxide, phorbol-12-myristate-13-acetate (PMA), and N-formyl-methionyl-leucyl-phenylalanine (FMLP). Cynarin, caffeic acid, chlorogenic acid, and luteolin, constituents of artichoke leaf extract, also show a concentration-dependent inhibitory activity in the above models, contributing to the antioxidant activity of the extract in human neutrophils.
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