Journal
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Volume 50, Issue 3, Pages 170-177Publisher
KARGER
DOI: 10.1159/000010319
Keywords
dysmenorrhea; vasopressin; vasopressin antagonist; Doppler ultrasound; intrauterine pressure
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We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F-2 alpha metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters, Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women. Copyright (C) 2000 S. Karger AG, Basel.
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