Journal
ACTA HAEMATOLOGICA
Volume 106, Issue 4, Pages 148-156Publisher
KARGER
DOI: 10.1159/000046610
Keywords
angiogenesis; apoptosis; endothelium; retinopathy; tumor growth; tyrosine kinases; vascular endothelial growth factor
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Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions. Copyright (C) 2001 S. Karger AG, Basel.
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