Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 12, Issue 9, Pages 979-993Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856201753252516
Keywords
collagen; PEO; nanofibers; fabrics; tissue engineering
Funding
- NHLBI NIH HHS [HL604064] Funding Source: Medline
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Type I collagen-PEO fibers and non-woven fiber networks were produced by the electrospinning of a weak acid solution of purified collagen at ambient temperature and pressure. As determined by high-resolution SEM and TEM, fiber morphology was influenced by solution viscosity, conductivity, and flow rate. Uniform fibers with a diameter range of 100-150 nm were produced from a 2-wt% solution of collagen-PEO at a flow rate of 100 mul min(-1). Ultimate tensile strength and elastic modulus of the resulting non-woven fabrics was dependent upon the chosen weight ratio of the collagen-PEO blend. H-1 NMR dipolar magnetization transfer analysis suggested that the superior mechanical properties, observed for collagen-PEO blends of weight ratio 1 : 1, were due to the maximization of intermolecular interactions between the PEO and collagen components. The process outlined herein provides a convenient, non-toxic, non-denaturing approach for the generation collagen-containing nanofibers and non-woven fabrics that have potential application in wound healing, tissue engineering, and as hemostatic agents.
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