Journal
PANCREATOLOGY
Volume 1, Issue 6, Pages 587-596Publisher
KARGER
DOI: 10.1159/000055868
Keywords
acinar cells; pancreatic duct; transcription factors; notch; stem cells; transdifferentiation
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Funding
- NIDDK NIH HHS [R01 DK56211-01] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK056211] Funding Source: NIH RePORTER
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Exocrine pancreatic cell types comprise greater than 90% of parenchymal cell mass in the adult pancreas. However, the factors regulating differentiation of acinar and ductal epithelial cells remain incompletely characterized. Like pancreatic islet cells, acinar and ductal cells arise from pluripotent precursors within embryonic pancreatic epithelium. Recent studies have suggested that a common pool of pluripotent stem cells is responsible for generating both endocrine and exocrine cell types, and that specific signaling pathways regulate a critical balance between endocrine and exocrine lineage commitment. Copyright (C) 2001 S. Karger AG, Basel and IAP.
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