Journal
DYES AND PIGMENTS
Volume 48, Issue 1, Pages 43-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0143-7208(00)00078-4
Keywords
oxazolonaphthalimide; hydroperoxide; DNA photocleave; plazmid nicking
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Novel oxazolonaphthalimide hydroperoxides 2 and 3 have been designed, synthesized and shown to be very efficient in photocleavage of DNA by the plazmid nicking assay. The absorption and fluorescence properties of these compounds and their relevant intermediates are discussed. An explanation for the higher DNA-cleavage efficiency of these oxazole-conjugated naphthalimide hydroperoxides than the nonsubstituted counterpart 1 is provided. (C) 2001 Elsevier Science Ltd. All rights reserved.
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