Journal
BREAST CANCER RESEARCH
Volume 3, Issue 4, Pages 224-229Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/bcr300
Keywords
apoptosis; basement membrane; integrin; mammary epithelial cell; three-dimensional tissue organization
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA078731] Funding Source: NIH RePORTER
- NCI NIH HHS [1 R01 CA78731-01A2, R01 CA078731] Funding Source: Medline
Ask authors/readers for more resources
Stromal-epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered tissue organization, disrupted tissue homeostasis and enhanced survival phenotype of the disease. Apoptosis resistance likely arises during malignant transformation via genetic and epigenetic modification of cell adhesion pathways induced by a changing tissue microenvironment. Acquisition of adhesion-linked survival networks that enhance MEC viability in the absence of basement membrane interactions probably promote malignant transformation, and may render breast tumors sufficiently resistant to exogenous apoptotic stimuli to generate multidrug resistance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available