Journal
ARTHRITIS RESEARCH
Volume 3, Issue 2, Pages 118-126Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar149
Keywords
chemokine; monocyte; rheumatoid arthritis
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Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P50AR039169] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR-39169] Funding Source: Medline
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Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.
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