Journal
BREAST CANCER RESEARCH
Volume 3, Issue 5, Pages 318-322Publisher
BMC
DOI: 10.1186/bcr314
Keywords
angiogenesis; apoptosis; glycolysis; macrophage
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The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia-regulated gene products and their associated pathways form the basis for the hypoxic promotion of tumourigenesis and malignant progression.
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