A new Ti-15Zr-4Nb-4Ta alloy for medical applications

V ions exhibit cytotoxicity in a culture medium from concentrations of greater than or equal to0.2 mg/L. Ti, Zr, Nb and Ta are biocompatible elements. A new Ti-15Zr-4Nb-4Ta alloy for medical implants is being developed. Its microstructure, mechanical properties, corrosion resistance and corrosion fatigue properties in a physiological saline solution, biocompatibility with cultured cells, new bone tissue response through rat tibia implantation and surface modification are discussed. Medical applications will be also addressed. (C) 2001 Elsevier Science Ltd. All rights reserved.