Journal
EUROPACE
Volume 3, Issue 1, Pages 29-38Publisher
OXFORD UNIV PRESS
DOI: 10.1053/eupc.2000.0136
Keywords
heart rate variability; spectral analysis; heart failure; sympathetic nervous system
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Spectral analysis of heart rate variability has gained popularity as a simple, non-invasive tool for assessing autonomic function in both normal subjects and in patients in a variety of clinical settings. However, the use of this method as a means of estimating the magnitude of cardiac sympathetic activation in individual patients with heart failure has proved disappointing, with a lack of concordance with more direct measures of sympathetic outflow. This review will describe the rationale involved in using sympathetic indices obtained from spectral analysis of heart rate variability to assess cardiac sympathetic outflow in normal subjects and patients with heart failure. The specific limitations and technological concerns that dictate how it may most effectively be used in this patient population will be discussed. (Europace 2001; 3: 29-38) (C) 2001 The European Society of Cardiology.
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