Journal
ARTHRITIS RESEARCH
Volume 3, Issue 4, Pages 221-227Publisher
BMC
DOI: 10.1186/ar305
Keywords
osteoclast; osteoprotegerin; receptor activator of nuclear factor-kappa B ligand; rheumatoid arthritis
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Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.
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