Journal
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume 16, Issue 1, Pages 21-25Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004850-200101000-00002
Keywords
post-traumatic stress disorder; adolescents; citalopram
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In this preliminary, 12-week open-label study, eight adolescents with moderate to severe post-traumatic stress disorder (PTSD) were treated with citalopram (the most selective of the selective serotonin reuptake inhibitors) in a fixed daily dose of 20 mg, and rated at 2-week intervals. The Clinician-Administered PTSD Stale (Child and Adolescent Version) was the primary measure used to assess treatment outcome. Core PTSD symptoms (re-experiencing, avoidance, and hyperarousal symptoms) showed statistically significant improvement at week 12 on the Clinician-Administered PTSD Scale (Child and Adolescent Version) (CAPS-CA), with a 38% reduction in total CAPS scores between baseline and endpoint. Citalopram failed to effect improvement on self-reported depressive symptoms. All seven adolescent completers were rated as much improved or very much improved on Clinical Global Impression Improvement stores. Citalopram was well-tolerated overall with reported adverse experiences being relatively benign. However, larger, controlled trials are needed to consolidate these preliminary results. Int Clin Psychopharmacol 16:21-25 (C) 2001 Lippincott Williams & Wilkins.
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