Journal
CHEMCATCHEM
Volume 6, Issue 6, Pages 1535-1537Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201400077
Keywords
biocatalysis; enantioselectivity; enzymes; reduction; sustainable chemistry
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Funding
- Deutsche Forschungsgemeinschaft training group 1166 BioNoCo (Biocatalysis in Non-conventional Media)
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Whole-cell biocatalysis with the use of baker's yeast is demonstrated in different mixtures of water with deep eutectic solvents (DESs; choline chloride/glycerol, 1:2 mol/mol). Enantioselective ketone reduction is observed for long reaction times (>200 h), which suggests that the whole cells remain stable in these neoteric solvents. By changing the proportion of the DES added, a complete inversion of enantioselectivity is observed, from approximately 95% enantiomeric excess (ee) (S) in pure water to approximately 95% ee (R) in the pure DES. Presumably, some (S)-oxidoreductases present in baker's yeast are inhibited by DESs.
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