Design of a Bifunctional Ir-Zr Based Metal-Organic Framework Heterogeneous Catalyst for the N-Alkylation of Amines with Alcohols

The direct N-alkylation of amines with alcohols was performed with an Ir-Zr-based metal-organic framework multifunctional heterogeneous catalyst. This system is efficient and environmentally benign for the synthesis of various organic amines in air in the absence of a base. The catalyst was recovered and reused without significant loss of activity, and only water was produced as a byproduct.