Journal
CHEMCATCHEM
Volume 6, Issue 8, Pages 2425-2431Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201402205
Keywords
asymmetric synthesis; biotransformations; enantioselectivity; ionic liquids; nitriles
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [236786/2012-1]
Ask authors/readers for more resources
The enantioselective reduction of a-methylene nitrile derivatives catalysed by ene-reductases affords the corresponding (R)-2-arylpropanenitriles with high conversion values. The reaction is investigated either in aqueous medium (with an organic cosolvent or by loading the substrate onto hydrophobic resins) or in a biphasic ionic liquid-water system. The use of ionic liquids, herein with isolated ene-reductases, is found to improve the work-up and the substrate recovery method. The synthetic manipulation of the final chiral nitrile derivatives indicates how this biocatalysed method can be exploited for the preparation of a wide range of chiral compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available