Journal
SCHIZOPHRENIA BULLETIN
Volume 27, Issue 3, Pages 497-502Publisher
US GOVERNMENT PRINTING OFFICE
DOI: 10.1093/oxfordjournals.schbul.a006890
Keywords
circadian rest-activity cycle; schizophrenia; neuroleptics; clozapine
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The circadian rest-activity cycle of schizophrenia patients stabilized for more than a year on monotherapy with a classical neuroleptic (haloperidol, flupentixol) or with the atypical neuroleptic clozapine was documented by continuous activity monitoring for 3-7 weeks. In this pilot study, the three patients treated with clozapine had remarkably highly ordered rest-activity cycles, whereas the four patients on classical neuroleptics had minor to major circadian rhythm abnormalities. This is the first documentation of circadian rest-activity cycle disturbances in schizophrenia related to class of drug.
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