Journal
CHEMCATCHEM
Volume 6, Issue 6, Pages 1543-1548Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201400011
Keywords
bovine serum albumin; enzyme mimics; nanoparticles; peroxidase; platinum
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Funding
- National Natural Science Foundation of China [21175023]
- Program for New Century Excellent Talents in University [NCET-12-0618]
- Natural Science Foundation of Fujian Province [2012J06019]
- Medical Elite Cultivation Program of Fujian, P.R.C [2013-ZQN-ZD-25]
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A green approach is proposed for the synthesis of Pt nanoparticles (PtNPs) in the bovine serum albumin (BSA) scaffold through biomineralization. The resulting BSA-PtNPs have been proved to function as peroxidase mimics that can catalyze the reaction of various peroxidase substrates in the presence of H2O2. Kinetic studies indicate that BSA-PtNPs have a much higher affinity for H2O2 than the NPs of other Pt-based peroxidase mimics. Furthermore, the BSA shell plays an important role in promoting the robust stability of PtNPs. Even in high ionic strength environment (2 M NaCl), the catalytic activity can be well preserved. These excellent properties make the BSA-PtNPs an ideal candidate for a wide range of potential applications as peroxidase mimics.
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