Journal
CRITICAL REVIEWS IN TOXICOLOGY
Volume 31, Issue 4-5, Pages 471-473Publisher
CRC PRESS LLC
DOI: 10.1080/20014091111758
Keywords
hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated
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This article proposes a general mechanism by which biphasic dose-response relationships occur in pharmacological and toxicological experimental systems. Such biphasic responses are mediated via a strategy of differential binding to stimulatory and inhibitory receptor subtypes based on agonist concentrations. Such a strategy is widely seen in pharmacological systems and has been demonstrated in toxicological-related biphasic dose responses in which the treatment altered levels of endogenous agonists.
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