Journal
MEDIATORS OF INFLAMMATION
Volume 10, Issue 2, Pages 51-59Publisher
CARFAX PUBLISHING
DOI: 10.1080/09629350120054518
Keywords
interleukin-10; interleukin-12; interferon-gamma; T-helper 1 and 2 cells; asthma; allergy
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INTERLEUKIN-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (TH2) cells identified as a suppressor of cytokines from T-helper type 1(T-H1) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates TH1 cell differentiation, while suppressing the expansion of T-H2 cell clones. Interferon-gamma (IFN-gamma) is a product of TH1 cells and exerts inhibitory effects on TH2 cell differentiation. These cytokines have been implicated in the pathogenesis of asthma and allergies. In this context, IL-12 and IFN-gamma production in asthma have been found to be decreased, and this may reduce their capacity to inhibit IgE synthesis and allergic inflammation. IL-10 is a potent inhibitor of monocyte/ macrophage function, suppressing the production of many pro-inflammatory cytokines. A relative underproduction of IL-10 from alveolar macrophages of atopic asthmatics has been reported. Therapeutic modulation of T-H1/T-H2 imbalance in asthma and allergy by mycobacterial vaccine, specific immunotherapy and cytoline-guanosine dinucleotide motif may lead to increases in IL-12 and IFN-gamma production. Stimulation of IL-10 production by antigen-specific T-cells during immunotherapy may lead to anergy through inhibition of CD28-costimulatory molecule signalling by IL-10s anti-inflammatory effect on basophils, mast cells and eosinophils.
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