Journal
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Volume 41, Issue -, Pages 203-236Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.pharmtox.41.1.203
Keywords
nitration; nitrosylation; reactive nitrogen species
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F32HL010046] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL10046-02] Funding Source: Medline
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Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many of these effects. However, NO can also interact with molecular oxygen and superoxide radicals to produce reactive nitrogen species that can modify a number of macromolecules including proteins, lipids, and nucleic acids. NO can also interact directly with transition metals. Here, we have reviewed the non-3',5'-cyclic-guanosine-monophosphate-mediated effects of NO including modifications of proteins, lipids, and nucleic acids.
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