Journal
CHEMCATCHEM
Volume 4, Issue 12, Pages 1889-1895Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201200533
Keywords
biocatalysis; cytochrome P450; green chemistry; hydroxylation; oxidation
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Funding
- Ministry of Innovation, Science and Research of North Rhine-Westphalia
- Heinrich-Heine-University Dusseldorf within the CLIB-Graduate Cluster Industrial Biotechnology
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Selective oxidations of readily available organic molecules can lead directly to high-value chiral compounds. Although modern chemical catalysts have significantly been improved toward the selective hydroxylation of nonactivated C?H bonds, cytochrome P450 monooxygenases still remain unsurpassed in their regio-, chemo-, and stereoselectivity. The exploitation of new P450 enzymes discovered through genome mining provides sought-after fine chemicals, drugs, drug metabolites, and vitamins and has already been proven superior to classical chemical synthesis in many cases. Here, we provide examples for highly selective oxidations achieved through the exploitation of naturally occurring (wild-type) P450 monooxygenases. We summarize recent achievements in the area of P450 biocatalysis and present examples for applications of P450s in industrial synthetic chemistry.
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