Journal
BIOSEPARATION
Volume 10, Issue 6, Pages 337-351Publisher
SPRINGER
DOI: 10.1023/A:1021550005389
Keywords
molecular imprinting; molecularly imprinted polymer; affinity separation; bioseparation; chiral separation; chiral stationary phases
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HPLC-based separations of amino acids and peptides, nucleotide bases, drugs, sugars and steroids using molecularly imprinted polymers (MIPs) have been reviewed in this article. The molecular recognition mechanisms of the template molecules on the MIPs in organic and aqueous eluents were discussed. Furthermore, new polymerization methods suitable for preparations of HPLC columns and packing materials using molecular imprinting techniques, and their applications to HPLC-based separations are also dealt with.
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