Journal
EXPERIMENTAL LUNG RESEARCH
Volume 27, Issue 1, Pages 1-12Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/019021401459734
Keywords
dogs; monocrotaline; neointima; pulmonary hypertension; vascular remodeling
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Funding
- NHLBI NIH HHS [P01 HL 13851] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL013851] Funding Source: NIH RePORTER
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We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromononcrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantly (P < .05) fr om 18 +/- 2 mm Hg at baseline to 30 +/- 4 nm Hg. Medial wall thickness and medial wall area as a percentage of total vessel diameter or area was significantly higher (P < .05) In group PH (29 +/- 48 and 48 +/- 12%) than in a control group (n = 5) (7 +/- 1% and 14 +/- 1%). Neointimal proliferation was observed in 42% of pulmonary arterioles in the PH group hut never in the control group. We conclude that a single injection of DHMC in young beagles, in addition to the development of moderate degrees of PH after 8 weeks, causes significant pulmonary vascular remodeling, with features similar to those observed in patients with primary PH.
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