Journal
JOURNAL OF DRUG TARGETING
Volume 9, Issue 6, Pages 431-438Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10611860108998777
Keywords
controlled release; microspheres; microparticles; poly(lactic-co-glycolic acid); tissue-engineering
Categories
Funding
- NIDCR NIH HHS [DE13018] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013018] Funding Source: NIH RePORTER
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The controlled release of proteins in tissue-engineered implants is being examined with the potential application to improve vascularization and hasten tissue growth. Bovine serum albumin (BSA), was encapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. The microparticles were coated with poly(vinyl alcohol) and incorporated into PLGA tissue-engineered scaffolds during fabrication. The release of BSA from PLGA microparticles, coated PLGA microparticles, and microparticles embedded in a porous PLGA scaffold was measured. We have developed a novel approach that will permit incorporation of coated polymeric microparticles during PLGA scaffold fabrication. Growth factors or drugs could be incorporated into the microparticles resulting in a long-term, controlled release.
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