Journal
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
Volume 10, Issue 3, Pages 281-302Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1011216131638
Keywords
Hirudo medicinalis; half-center oscillator; central pattern generator
Funding
- NINDS NIH HHS [NS24072, NS10130] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS024072, R56NS024072, F32NS010130] Funding Source: NIH RePORTER
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We modeled a segmental oscillator of the timing network that paces the heartbeat of the leech. This model represents a network of six heart interneurons that comprise the basic rhythm-generating network within a single ganglion. This model builds on a previous two cell model (Nadim et al., 1995) by incorporating modifications of intrinsic and synaptic currents based on the results of a realistic waveform voltage-clamp study (Olsen and Calabrese, 1996). Due to these modifications, the new model behaves more similarly to the biological system than the previous model. For example, the slow-wave oscillation of membrane potential that underlies bursting is similar in form and amplitude to that of the biological system. Furthermore, the new model with its expanded architecture demonstrates how coordinating interneurons contribute to the oscillations within a single ganglion, in addition to their role of intersegmental coordination.
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