Journal
CHEMBIOCHEM
Volume 20, Issue 4, Pages 437-450Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800430
Keywords
activatable probes; biosensors; functional imaging; nanotechnology; nucleic acids
Funding
- NTU-Northwestern Institute for Nanomedicine
- Singapore A*STAR Biomedical Research Council (IAF-PP grant)
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Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.
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