Journal
CHEMBIOCHEM
Volume 15, Issue 10, Pages 1465-1470Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201402087
Keywords
actin; cancer; galectin; polycations; tenascin
Funding
- Grant Agency of the Ministry of Health of the Czech Republic [13488-4]
- Charles University [PRVOUK-27-1, UNCE 204013]
- Specific University Research grant from the European Regional Development Fund BIOCEV [CZ.1.05/1.1.00/02.0109]
- EC FP7 program [317297]
- CNRS
- University of Strasbourg
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Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle alpha-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the anionic actin. We tested the effect of the synthetic polyamine BPA-C8 on the transition of human dermal fibroblasts to myofibroblasts induced either by TGF-beta 1 alone or by TGF-beta 1 together with adhesion/growth-regulatory galectin-1. Pre-existing CAFs, myofi-broblasts from pancreatitis, and rat smooth muscle cells were also exposed to BPA-C8. BPA-C8 impaired myofibroblast formation from activated fibroblasts, but it had no effect on cells already expressing SMA. BPA-C8 also reduced the occurrence of an extracellular matrix around the activated fibroblasts. The reported data thus extend current insights into polyamine activity, adding interference with tumor progression to the tumor-promoting processes warranting study.
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