Journal
CHEMBIOCHEM
Volume 15, Issue 17, Pages 2590-2597Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201402404
Keywords
natural products; quorum sensing; ralfuranones; Ralstonia solanacearum; structure elucidation
Funding
- Agricultural Chemical Research Foundation
- JSPS KAKENHI [26660036]
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Ralstonia solanacearum causes a destructive disease called bacterial wilt in numerous plant species. Its virulence is controlled by the transcriptional regulator PhcA, the activity of which is, in turn, regulated in a cell-density dependent manner, termed quorum sensing. We herein described the identification and characterization of ralfuranones J-L, new PhcA-regulated secondary metabolites, and the known derivatives, ralfuranones A and B, from R. solanacearum strain OE1-1. Their structures were determined by spectroscopic and chemical methods. These ralfuranones were also detected in vascular exudates from host plants infected with OE1-1. Deletion of ralA, which encodes an enzyme for ralfuranone biosynthesis, reduced the virulence of OE1-1 in tomato plants. Virulence was restored by complementation of the ralA gene. The results suggest that ralfuranones play important roles in the virulence of OE1-1.
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