Journal
INTERVIROLOGY
Volume 44, Issue 1, Pages 48-54Publisher
KARGER
DOI: 10.1159/000050030
Keywords
dengue virus; persistent infection; electron microscopy; apoptosis; Raji cells
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We investigated persistent infection of Epstein-Barr virus (EBV)-transformed lymphoblastoid cells with dengue virus using a transmission electron microscope. Most of the infected cells kept an intact morphology with only a few vi rus particles in the cytoplasm, but without any indication of active viral replication. Some cells were apoptotic and a few dengue virus particles were present in these apoptotic cells. Raji cells acutely infected with dengue-2 virus showed degenerative morphology. There were membranous tubular structures and many virus particles around and within the infected cells. Approximately 95% of the cells were dengue viral antigen positive in the persistently infected EBV-transformed cell line. It is likely that persistent infection is maintained mainly by the division of infected cells without cytopathic effect by dengue-2 virus. Copyright (C) 2001 S. Karger AG, Basel.
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