Journal
CHEMBIOCHEM
Volume 14, Issue 14, Pages 1876-1882Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201300172
Keywords
heteronuclear NMR; HPV; IDP; viral proteins
Funding
- Joint Research Activity and Access to Research Infrastructures (BioNMR) [261863]
- Marie Curie ITN programs (IDPbyNMR) in the EC 7th Framework [264257]
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The E7 protein from human papillomavirus (HPV) plays a key role in oncogenesis; for this reason, it is a target of great biomedical interest. To date, no high resolution information is available for the full protein. We present here the NMR characterization of the entire E7 from HPV16, one of the most oncogenic variants of the virus. The protein is very heterogeneous in terms of structural and dynamic properties with a highly flexible N-terminal module and a more structured C terminus. This opens possibilities for studies of molecular-level interactions and post-translational modifications of the protein to unravel functional details that might be linked to its highly oncogenic potential.
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