Journal
CHEMBIOCHEM
Volume 14, Issue 15, Pages 1991-1997Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201300205
Keywords
biosynthesis; insect inducible genes; natural products; promoter trap strategy; rhabdopeptides; Xenorhabdus
Funding
- DFG
- ERC [311477]
- Biotechnology and Biological Sciences Research Council [BB/E021182/1] Funding Source: researchfish
- BBSRC [BB/E021182/1] Funding Source: UKRI
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Six novel linear peptides, named rhabdopeptides, have been identified in the entomopathogenic bacterium Xenorhabdus nematophila after the discovery of the corresponding rdp gene cluster by using a promoter trap strategy for the detection of insect-inducible genes. The structures of these rhabdopeptides were deduced from labeling experiments combined with detailed MS analysis. Detailed analysis of an rdp mutant revealed that these compounds participate in virulence towards insects and are produced upon bacterial infection of a suitable insect host. Furthermore, two additional rhabdopeptide derivatives produced by Xenorhabdus cabanillasii were isolated, these showed activity against insect hemocytes thereby confirming the virulence of this novel class of compounds.
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