4.4 Review

Intrinsically Disordered Proteins: From Sequence and Conformational Properties toward Drug Discovery

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Monomeric α-Synuclein Binds Congo Red Micelles in a Disordered Manner

Alexander S. Maltsev et al.

BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Folding and misfolding of alpha-synuclein on membranes

Igor Dikiy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Review Biochemistry & Molecular Biology

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

Pau Bernado et al.

MOLECULAR BIOSYSTEMS (2012)

Review Biochemistry & Molecular Biology

Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy

Robert Schneider et al.

MOLECULAR BIOSYSTEMS (2012)

Article Chemistry, Multidisciplinary

Characteristics of Human Lysozyme and Its Disease-Related Mutants in their Unfolded States

Friederike Sziegat et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Chemistry, Multidisciplinary

The Dynamic Structure of Filamentous Tau

Stefan Bibow et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Biochemistry & Molecular Biology

NSAID-Based γ-Secretase Modulators Do Not Bind to the Amyloid-β Polypeptide

Paul J. Barrett et al.

BIOCHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Protein folding at single-molecule resolution

Allan Chris M. Ferreon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)

Article Biophysics

Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation

Nasrollah Rezaei-Ghaleh et al.

BIOPHYSICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Constructing ensembles for intrinsically disordered proteins

Charles K. Fisher et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Unstructural biology coming of age

Peter Tompa

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Intrinsically disordered proteins: regulation and disease

M. Madan Babu et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly

Gonzalo R. Lamberto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

5D 13C-detected experiments for backbone assignment of unstructured proteins with a very low signal dispersion

Jiri Novacek et al.

JOURNAL OF BIOMOLECULAR NMR (2011)

Article Biochemistry & Molecular Biology

Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH

Magnus Kjaergaard et al.

JOURNAL OF BIOMOLECULAR NMR (2011)

Article Chemistry, Multidisciplinary

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

Stefan Bibow et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Multidisciplinary Sciences

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

Nahuai Badiola et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

Lise Giehm et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Chemistry, Physical

Interpreting protein chemical shift data

David S. Wishart

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2011)

Article Biochemistry & Molecular Biology

SAXS Ensemble Refinement of ESCRT-III CHMP3 Conformational Transitions

Bartosz Rozycki et al.

STRUCTURE (2011)

Article Biochemistry & Molecular Biology

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

Bin Xue et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Biophysics

Proline-Rich Salivary Proteins Have Extended Conformations

Helene Boze et al.

BIOPHYSICAL JOURNAL (2010)

Article Mathematical & Computational Biology

Archaic chaos: intrinsically disordered proteins in Archaea

Bin Xue et al.

BMC SYSTEMS BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Intrinsically disordered proteins are potential drug targets

Steven J. Metallo

CURRENT OPINION IN CHEMICAL BIOLOGY (2010)

Article Pharmacology & Pharmacy

Drugs for 'protein clouds': targeting intrinsically disordered transcription factors

A. Keith Dunker et al.

CURRENT OPINION IN PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains

Katherine Stott et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Structural characterization of proteins and complexes using small-angle X-ray solution scattering

Haydyn D. T. Mertens et al.

JOURNAL OF STRUCTURAL BIOLOGY (2010)

Article Chemistry, Multidisciplinary

Molten Globule Precursor States Are Conformationally Correlated to Amyloid Fibrils of Human β-2-Microglobulin

Lukasz Skora et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Refinement of Ensembles Describing Unstructured Proteins Using NMR Residual Dipolar Couplings

Santi Esteban-Martin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Defining Conformational Ensembles of Intrinsically Disordered and Partially Folded Proteins Directly from Chemical Shifts

Malene Ringkjobing Jensen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Ensemble Calculations of Unstructured Proteins Constrained by RDC and PRE Data: A Case Study of Urea-Denatured Ubiquitin

Jie-rong Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Automatic Assignment of the Intrinsically Disordered Protein Tau with 441-Residues

Rhagavendran L. Narayanan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Sequence-Specific Random Coil Chemical Shifts of Intrinsically Disordered Proteins

Kamil Tamiola et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

NMR Characterization of Long-Range Order in Intrinsically Disordered Proteins

Loic Salmon et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Biochemistry & Molecular Biology

ELM: the status of the 2010 eukaryotic linear motif resource

Cathryn M. Gould et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemistry & Molecular Biology

SLiMFinder: a web server to find novel, significantly over-represented, short protein motifs

Norman E. Davey et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization

Luise Richter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Multidomain assembled states of Hck tyrosine kinase in solution

Sichun Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

Small-angle scattering for structural biology-Expanding the frontier while avoiding the pitfalls

David A. Jacques et al.

PROTEIN SCIENCE (2010)

Article Multidisciplinary Sciences

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution

Dmitry M. Korzhnev et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein

Andrew J. Beel et al.

BIOCHEMISTRY (2009)

Review Cell Biology

Predicting intrinsic disorder in proteins: an overview

Bo He et al.

CELL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Biophysical characterization of intrinsically disordered proteins

David Eliezer

CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Linking folding and binding

Peter E. Wright et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Enhanced alpha-Synuclein Expression in Human Neurodegenerative Diseases: Pathogenetic and Therapeutic Implications

Alison L. McCormack et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2009)

Article Biochemistry & Molecular Biology

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

Marcello Clerici et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response

Peter Tsvetkov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Structural Interpretation of Paramagnetic Relaxation Enhancement-Derived Distances for Disordered Protein States

Debabani Ganguly et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Chemistry, Multidisciplinary

Exact Distances and Internal Dynamics of Perdeuterated Ubiquitin from NOE Buildups

Beat Voegeli et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Quantitative Description of Backbone Conformational Sampling of Unfolded Proteins at Amino Acid Resolution from NMR Residual Dipolar Couplings

Gabrielle Nodet et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Fast and Accurate Predictions of Protein NMR Chemical Shifts from Interatomic Distances

Kai J. Kohlhoff et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

Dalia I. Hammoudeh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Determination of the Free Energy Landscape of α-Synuclein Using Spin Label Nuclear Magnetic Resonance Measurements

Jane R. Allison et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Biochemistry & Molecular Biology

The nanny model for IDPs

Peter Tsvetkov et al.

NATURE CHEMICAL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

NMR spectroscopy brings invisible protein states into focus

Andrew J. Baldwin et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Multidisciplinary Sciences

Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence

Allan Chris M. Ferreon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

Fang Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation

Gonzalo R. Lamberto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

Marco D. Mukrasch et al.

PLOS BIOLOGY (2009)

Article Biochemical Research Methods

Prediction of Protein Binding Regions in Disordered Proteins

Balint Meszaros et al.

PLOS COMPUTATIONAL BIOLOGY (2009)

Review Biophysics

Intrinsically disordered proteins in human diseases: Introducing the D-2 concept

Vladimir N. Uversky et al.

ANNUAL REVIEW OF BIOPHYSICS (2008)

Article Biochemical Research Methods

Prediction of disordered regions in proteins based on the meta approach

Takashi Ishida et al.

BIOINFORMATICS (2008)

Article Biotechnology & Applied Microbiology

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

Christopher J. Oldfield et al.

BMC GENOMICS (2008)

Article Biochemistry & Molecular Biology

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein

Katerina E. Paleologou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Calculation of residual dipolar couplings from disordered state ensembles using local alignment

Joseph A. Marsh et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Chemistry, Multidisciplinary

Kinetics of folding and binding of an intrinsically disordered protein: The inhibitor of yeast aspartic proteinase YPrA

Ranjani Narayanan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Multidisciplinary Sciences

Substrate-targeting γ-secretase modulators

Thomas L. Kukar et al.

NATURE (2008)

Editorial Material Multidisciplinary Sciences

Proteins with weakly funneled energy landscapes challenge the classical structure-function paradigm

Garegin A. Papoian

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

Peter Tompa et al.

TRENDS IN BIOCHEMICAL SCIENCES (2008)

Article Biochemical Research Methods

The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau

Austin Huang et al.

PLOS COMPUTATIONAL BIOLOGY (2008)

Article Chemistry, Multidisciplinary

Interaction of urea with amino acids:: Implications for urea-induced protein denaturation

Martin C. Stumpe et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemistry & Molecular Biology

Mining α-helix-forming molecular recognition features with cross species sequence alignments

Yugong Cheng et al.

BIOCHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Correlation of amyloid fibril β-structure with the unfolded state of α-synuclein

Hai-Young Kim et al.

CHEMBIOCHEM (2007)

Article Chemistry, Multidisciplinary

Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR Spectroscopy

Sebastian Hiller et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemistry & Molecular Biology

Theoretical framework for NMR residual dipolar couplings in unfolded proteins

O. I. Obolensky et al.

JOURNAL OF BIOMOLECULAR NMR (2007)

Article Chemistry, Multidisciplinary

Mapping the conformational landscape of urea-denatured ubiquitin using residual dipolar couplings

Sebastian Meier et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemistry & Molecular Biology

Protein backbone chemical shifts predicted from searching a database for torsion angle and sequence homology

Yang Shen et al.

JOURNAL OF BIOMOLECULAR NMR (2007)

Article Chemistry, Physical

An exact formulation of hyperdynamics simulations

L. Y. Chen et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

Article Chemistry, Multidisciplinary

Structural characterization of flexible proteins using small-angle X-ray scattering

Pau Bernado et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Chemistry, Multidisciplinary

Highly populated turn conformations in natively unfolded Tau protein identified from residual dipolar couplings and molecular simulation

Marco D. Mukrasch et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Chemistry, Multidisciplinary

Amino acid bulkiness defines the local conformations and dynamics of natively unfolded α-synuclein and tau

Min-Kyu Cho et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Multidisciplinary Sciences

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures

Samrat Mukhopadhyay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Biochemistry & Molecular Biology

Atomic-level characterization of disordered protein ensembles

Tanja Mittag et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)

Article Chemistry, Multidisciplinary

Fly-casting in protein-DNA binding: Frustration between protein folding and electrostatics facilitates target recognition

Yaakov Levy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Chemistry, Multidisciplinary

Direct observation of dipolar couplings and hydrogen bonds across a β-hairpin in 8 M urea

Sebastian Meier et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemical Research Methods

Characterization of molecular recognition features, MoRFs, and their binding partners

Vladimir Vacic et al.

JOURNAL OF PROTEOME RESEARCH (2007)

Article Biochemistry & Molecular Biology

DisProt: the database of disordered proteins

Megan Sickmeier et al.

NUCLEIC ACIDS RESEARCH (2007)

Review Biophysics

Intrinsic disorder and functional proteomics

Predrag Radivojac et al.

BIOPHYSICAL JOURNAL (2007)

Review Biochemistry & Molecular Biology

Analysis of molecular recognition features (MoRFs)

Amrita Mohan et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease

Christopher J. Francis et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Article Biochemical Research Methods

Length-dependent prediction of protein intrinsic disorder

Kang Peng et al.

BMC BIOINFORMATICS (2006)

Review Chemistry, Physical

13C-detected protonless NMR spectroscopy of proteins in solution

W Bermel et al.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2006)

Article Chemistry, Multidisciplinary

NMR analysis of a Tau phosphorylation pattern

I Landrieu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Article Multidisciplinary Sciences

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

LM Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Polyproline II conformation is one of many local conformational states and is not an overall conformation of unfolded peptides and proteins

J Makowska et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Clinical Neurology

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

M. von Bergen et al.

NEURODEGENERATIVE DISEASES (2006)

Article Chemistry, Multidisciplinary

Defining long-range order and local disorder in native α-synuclein using residual dipolar couplings

P Bernadó et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Chemistry, Multidisciplinary

Tertiary contact formation in α-synuclein probed by electron transfer

JC Lee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Multidisciplinary Sciences

A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering

P Bernadó et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Flexible nets - The roles of intrinsic disorder in protein interaction networks

AK Dunker et al.

FEBS JOURNAL (2005)

Review Biochemistry & Molecular Biology

Coupled folding and binding with α-helix-forming molecular recognition elements

CJ Oldfield et al.

BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Statistical coil model of the unfolded state: Resolving the reconciliation problem

AK Jha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

FoldIndex©:: a simple tool to predict whether a given protein sequence is intrinsically unfolded

J Prilusky et al.

BIOINFORMATICS (2005)

Review Biochemistry & Molecular Biology

The interplay between structure and function in intrinsically unstructured proteins

P Tompa

FEBS LETTERS (2005)

Article Biochemistry & Molecular Biology

Urea promotes polyproline II helix formation: Implications for protein denatured states

SJ Whittington et al.

BIOCHEMISTRY (2005)

Review Cell Biology

Intrinsically unstructured proteins and their functions

HJ Dyson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Biochemistry & Molecular Biology

Comparing and combining predictors of mostly disordered proteins

CJ Oldfield et al.

BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein

CW Bertoncini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

Natively unfolded proteins

AL Fink

CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Sequence patterns associated with disordered regions in proteins

S Lise et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)

Article Biochemistry & Molecular Biology

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

ER Lacy et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life

JJ Ward et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Article Biochemical Research Methods

The DISOPRED server for the prediction of protein disorder

JJ Ward et al.

BIOINFORMATICS (2004)

Article Multidisciplinary Sciences

Random-coil behavior and the dimensions of chemically unfolded proteins

JE Kohn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Chemistry, Multidisciplinary

NMR characterization of the dynamics of biomacromolecules

AG Palmer

CHEMICAL REVIEWS (2004)

Review Chemistry, Multidisciplinary

Unfolded proteins and protein folding studied by NMR

HJ Dyson et al.

CHEMICAL REVIEWS (2004)

Article Biochemistry & Molecular Biology

Structural characterization of unfolded states of apomyoglobin using residual dipolar couplings

R Mohana-Borges et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Short-range, long-range and transition state interactions in the denatured state of ACBP from residual dipolar couplings

W Fieber et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Protein interaction networks from yeast to human

P Bork et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Protein flexibility and intrinsic disorder

P Radivojac et al.

PROTEIN SCIENCE (2004)

Article Biochemistry & Molecular Biology

Preformed structural elements feature in partner recognition by intrinsically unstructured proteins

M Fuxreiter et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The N-terminal domain of p53 is natively unfolded

R Dawson et al.

JOURNAL OF MOLECULAR BIOLOGY (2003)

Review Biochemistry & Molecular Biology

Intrinsically unstructured proteins evolve by repeat expansion

P Tompa

BIOESSAYS (2003)

Article Biochemistry & Molecular Biology

Aromatic and methyl NOES highlight hydrophobic clustering in the unfolded state of an SH3 domain

KA Crowhurst et al.

BIOCHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Rapid and accurate calculation of protein 1H, 13C and 15N chemical shifts

S Neal et al.

JOURNAL OF BIOMOLECULAR NMR (2003)

Article Biochemistry & Molecular Biology

NORSp: predictions of long regions without regular secondary structure

JF Liu et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

GlobPlot: exploring protein sequences for globularity and disorder

R Linding et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Predicting intrinsic disorder from amino acid sequence

Z Obradovic et al.

PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)

Article Biochemistry & Molecular Biology

Protein disorder prediction: Implications for structural proteomics

R Linding et al.

STRUCTURE (2003)

Article Biochemistry & Molecular Biology

Transient structure formation in unfolded acyl-coenzyme A-binding protein observed by site-directed spin labelling

K Teilum et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Intrinsic disorder in cell-signaling and cancer-associated proteins

LM Iakoucheva et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Proteasomal degradation of tau protein

DC David et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Review Oncology

Live or let die: The cell's response to p53

KH Vousden et al.

NATURE REVIEWS CANCER (2002)

Review Biochemistry & Molecular Biology

Natively unfolded proteins: A point where biology waits for physics

VN Uversky

PROTEIN SCIENCE (2002)

Review Biochemistry & Molecular Biology

Coupling of folding and binding for unstructured proteins

HJ Dyson et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Equilibrium collapse and the kinetic 'foldability' of proteins

IS Millet et al.

BIOCHEMISTRY (2002)

Article Multidisciplinary Sciences

Long-range interactions within a nonnative protein

J Klein-Seetharaman et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Automated prediction of 15N, 13Cα, 13Cβ and 13C′ chemical shifts in proteins using a density functional database

XP Xu et al.

JOURNAL OF BIOMOLECULAR NMR (2001)

Article Chemistry, Multidisciplinary

Single-step determination of protein substructures using dipolar couplings: Aid to structural genomics

M Zweckstetter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

Article Biochemistry & Molecular Biology

Conformational properties of α-synuclein in its free and lipid-associated states

D Eliezer et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Chemistry, Multidisciplinary

Sequence-dependent correction of random coil NMR chemical shifts

S Schwarzinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

Article Biochemical Research Methods

Intrinsically disordered protein

AK Dunker et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2001)

Article Biochemistry & Molecular Biology

Local structural elements in the mostly unstructured transcriptional activation domain of human p53

H Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

Speeding molecular recognition by using the folding funnel: The fly-casting mechanism

BA Shoemaker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Chemistry, Multidisciplinary

Prediction of sterically induced alignment in a dilute liquid crystalline phase: Aid to protein structure determination by NMR

M Zweckstetter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)

Article Biochemistry & Molecular Biology

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

RJ Sheaff et al.

MOLECULAR CELL (2000)

Article Biochemistry & Molecular Biology

Intensity modulated HSQC and HMQC: Two simple methods to measure (3)J(HNH alpha) in proteins

P Permi et al.

JOURNAL OF BIOMOLECULAR NMR (2000)