Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 184, Issue 2, Pages 104-110Publisher
MOSBY, INC
DOI: 10.1067/mob.2001.107919
Keywords
deep vein thrombosis; pulmonary embolism; pregnancy; puerperium
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL060279] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR030582] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL46974, HL60279] Funding Source: Medline
- NIAMS NIH HHS [AR30582] Funding Source: Medline
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OBJECTIVE: We sought to determine risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum. STUDY DESIGN: We performed a population-based case-control study. All Olmsted County, Minnesota, residents with a first lifetime deep vein thrombosis or pulmonary embolism during pregnancy or post partum from 1966 to 1990 were identified (N = 90). Where possible, a resident without deep vein thrombosis or pulmonary embolism was matched to each patient by dale of the first live birth after the patient's child. The medical records of all remaining patients and all control subjects were reviewed for >25 baseline characteristics, which were tested as risk factors for deep vein thrombosis or pulmonary embolism. RESULTS: In multivariate analysis smoking (odds ratio, 2.4) and prior superficial vein thrombosis (odds ratio, 9.4) were independent risk factors for deep vein thrombosis or pulmonary thrombosis during pregnancy or post partum. CONCLUSION: Venous thromboembolism prophylaxis may be warranted for pregnant women with prior superficial Vein thrombosis. Smoking cessation should be recommended, especially during pregnancy and the postpartum period.
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