Journal
INFECTION AND IMMUNITY
Volume 69, Issue 1, Pages 538-542Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.1.538-542.2001
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Twelve Pseudomonas aeruginosa cystic fibrosis isolates that are not able to exert a type III secretion system (TTSS)-dependent cytotoxicity towards phagocytes have been further studied. The strains, although possessing TTSS genes and exsA, which encodes a positive regulator of the TTSS regulon, showed no transcriptional activation of the exsCBA regulatory operon. The expression of exsA in trans restored the in vitro secretion of TTSS proteins and ex vivo cytotoxicity.
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