Journal
CHEMBIOCHEM
Volume 11, Issue 2, Pages 152-160Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200900618
Keywords
foldamers; hybrid backbones; medicinal chemistry; peptidomimetics; peptoids
Funding
- Benzon Foundation
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Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with beta-peptides and the so-called peptoids (N-alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both alpha- and beta-amino acids (alpha/ beta-peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of alpha-amino acids and peptoids, including beta-peptoids (N-alkyl-beta-alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.
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