Journal
CHEMBIOCHEM
Volume 10, Issue 8, Pages 1369-1378Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200900024
Keywords
calixarenes; click chemistry; glycoarrays; glycoclusters; multivalency
Funding
- CNRS
- ANR [ANR-08-BLAN-0114-01]
- Lyon Biopole
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0114] Funding Source: Agence Nationale de la Recherche (ANR)
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Interactions between proteins and carbohydrates are involved in a large number of crucial biological events. Many efforts have been devoted to the design and synthesis of unnatural saccharides displaying high affinities towards targeted lectins. Among others, glycoside clusters have proven to be valuable tools for these recognition studies. However, the spatial arrangements of the sugar residues are a key issue in the design of high-affinity glycoclusters. Here, the affinities of linear and antenna- and calixarene-based galactoside clusters against two lectins, derived from Pseudomonas aeruginosa and Ricinus communis, have been compared by means of glycoarrays.
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