Journal
CHEMBIOCHEM
Volume 9, Issue 8, Pages 1303-1307Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200700651
Keywords
glutamate cage; neurotransmitters; photolabile protecting groups; photolysis; two-photon uncaging
Funding
- Medical Research Council [U117512659] Funding Source: researchfish
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A pi-extended [2-(2-nitrophenyl)propoxy]corbonyl (NPPOC) derivative has been prepared as an efficient UV and near-IR photolabile protecting group for glutamate. This glutamate cage compound exhibits efficient photorelease upon one-photon excitation (epsilon Phi = 990m(-1) cm(-1) at 315 nm). In addition, it also shows efficient photorelease in activation of glutamate receptors in electrophysiological recordings. Combined with a high two-photon uncaging I cross-section (delta Phi = 0.45 GM at 800 nm), its overall properties make this new cage-3-(2-propyl)-4'-methoxy-4-nitrobiphenyl (PMNB)-for glutamate a very promising tool for two-photon neuronal studies.
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