Journal
CHEMBIOCHEM
Volume 9, Issue 7, Pages 1154-1158Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200700761
Keywords
cell imaging; chemokine receptors; CXCR4 antagonists; fluorescent probes; peptides
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The design, synthesis, and bioevaluation of fluorescence- and biotin-labeled CXCR4 antagonists are described The modification Of D-Lys8 at an e-amino group in the peptide antagonist Ac-TZ14071 derived from polyphemusin II hod no significant influence on the potent binding of the peptide to the CXCR4 receptor. The application of the labeled peptides in flow cytometry and confocal microscopy studies demonstrated the selectivity of their binding to the CXCR4 receptor, but not to CXCR7, which was recently, reported to be another receptor for stromal cell-derived factor 1 (SDF-1)/CXCL12.
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