4.7 Article

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 45, Issue 1, Pages 319-323

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.1.319-323.2001

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Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.

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