Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 158, Issue 1, Pages 137-139Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.158.1.137
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [K21MH001230] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH01230] Funding Source: Medline
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Objective: Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD. Method: The authors used the Rey-Osterrieth Complex Figure Test and the California Verbal Learning Test to compare memory functioning of 37 adult OCD patients with self-reported childhood onset of symptoms (onset at less than 18 years of age) with that of 31 patients with adult-onset symptoms. Results: No differences were found between the two groups on any of the verbal and nonverbal memory measures. Conclusions: Self-reported age at symptom onset is not associated with memory performance in adult patients with OCD according to tests previously found to be sensitive to frontal-striatal system dysfunction and impairment in OCD. Such dysfunction appears to be a consistent feature of OCD in adults, regardless of age at initial symptom onset.
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