One-pot highly diastereoselective synthesis of new 2-substituted 8-(spiro-3 '-indolino-2 '-one)-pyrrolo[3,4-a]pyrrolizine-1,3-diones mediated by azomethine ylide induced by microwave irradiation

Isatin derivatives react with proline and N-Aryl Maleimides via decarboxylative azomethine ylide formation and subsequent 1,3-dipolar cycloaddition involving an exo-transition state to give new heterocyclic adducts in 71-94% yield.