4.3 Article

N-3-alkylation of uracil and derivatives via N-1-BOC protection

Journal

SYNTHETIC COMMUNICATIONS
Volume 31, Issue 24, Pages 3739-3746

Publisher

MARCEL DEKKER INC
DOI: 10.1081/SCC-100108223

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An easy and efficient synthesis of 3-alkyluracils is described. Thus, BOC-protection at N-1 of uracil permits selective alkylation at N-3. This protecting group can be removed under very mild conditions.

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