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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

Journal

NATURE MEDICINE
Volume 7, Issue 1, Pages 33-40

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/83324

Keywords

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Funding

  1. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL064274] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR044526] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK049022] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM034534] Funding Source: NIH RePORTER
  5. NHLBI NIH HHS [HL64274] Funding Source: Medline
  6. NIAMS NIH HHS [AR44526] Funding Source: Medline
  7. NIDDK NIH HHS [DK49022] Funding Source: Medline
  8. NIGMS NIH HHS [GM34534] Funding Source: Medline
  9. Telethon [B.58] Funding Source: Medline

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Considered by some to be among the simpler forms of life, viruses represent highly evolved natural vectors for the transfer of foreign genetic information into cells. This attribute has led to extensive attempts to engineer recombinant viral vectors for the delivery of therapeutic genes into diseased tissues. While substantial progress has been made, and some clinical successes are over the horizon, further vector refinement and/or development is required before gene therapy will become standard care for any individual disorder.

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