Journal
NATURE MEDICINE
Volume 7, Issue 1, Pages 73-79Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/83381
Keywords
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Funding
- NATIONAL CANCER INSTITUTE [U01CA066529, R01CA042059] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI041536] Funding Source: NIH RePORTER
- NCI NIH HHS [CA42059, CA66529] Funding Source: Medline
- NIAID NIH HHS [AI01597, AI41536] Funding Source: Medline
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We hypothesized that HIV-1-mediated T-cell loss might induce the production of factors that are capable of stimulating lymphocyte development and expansion. Here we perform cross-sectional (n = 168) and longitudinal (n = 11) analyses showing that increased circulating levels of interleukin (IL)-7 are strongly associated with CD4+ T lymphopenia in HIV-1 disease. Using immunohistochemistry with quantitative image analysis, we demonstrate that IL-7 is produced by dendritic-like cells within peripheral lymphoid tissues and that IL-7 production by these cells is greatly increased in lymphocyte-depleted tissues. We propose that IL-7 production increases as part of a homeostatic response to T-cell depletion.
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