Synthesis of 2-alkyl and 2-aryl pyrimidines from beta-chlorovinyl ketones of cyclopentanone type

Amidines react in the presence of NaHCO3 with beta -chlorovinyl ketones, prepared regioselectively by the reaction off 2-acetylcyclopentanone-type diketones with PPh3-CCl4 in 73-78% yield, to afford 2-alkyl (aryl)-pyrimidines annelated with cyclopentane derivatives in 79-87% yields.