Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 1, Pages 125-126Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000381u
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The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.
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