Journal
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
Volume -, Issue 6, Pages 929-933Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b100405k
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A series of Gd-DO3A derivatives (8a-d) mimicking phospholipids have been prepared. Two of the complexes, Gd-HADB-DO3A (8a) and Gd-HADO-DO3A (8b), have been evaluated as pH responsive MRI contrast agents in vitro. The T-1-relaxivity (r(1)) of Gd-HADO-DO3A (8b) increased 142% on changing the pH from 6 to 8. The pH dependence is thought to arise from the formation of supramolecular structures caused by deprotonation of the amphiphilic complex at alkaline pH.
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